Key result
Novel porcine model successfully induces DVT and triggers confirmed PE in ~60% of animals.
Why the study?
Venous thromboembolism is a severe disease with high morbidity and mortality, prompting the need to establish a new porcine model based on in vivo thrombus formation.
This study successfully establishes a novel in vivo porcine model of venous thromboembolism that induces both DVT and PE in the same animal, providing a platform for future therapeutic testing.
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Offers a porcine VTE model for preclinical testing; hypothesis-generating and should not yet change practice.
Venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), is a severe disease affecting the human venous system, accompanied by high morbidity and mortality rates. The aim of the study was to establish a new porcine VTE model based on the formation of the thrombus in vivo. The study was performed on 10 castrated male pigs: thrombus was formed in each closed femoral vein and then successfully released from the right femoral vein into the circulation of animals. In six pigs PE was confirmed via both computed tomography pulmonary angiography and an autopsy. Our research presents a novel experimental porcine model of VTE that involves inducing DVT and PE in the same animal in vivo, making it suitable for advanced clinical research and testing of future therapies.
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Gromadziński et al. (2021) studied Venous thromboembolism (VTE) (n=10). In vivo thrombus formation in closed femoral vein and release into circulation was evaluated on Confirmation of pulmonary embolism (PE) via computed tomography pulmonary angiography and autopsy. A novel experimental porcine model successfully induced deep vein thrombosis and pulmonary embolism in vivo, with PE confirmed in 60% (6 of 10) of the animals.
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