Why the study?
While sheep have traditionally served as the standard for preclinical cardiovascular testing, pigs are considered a superior option due to a more comparable coagulation system.
Do pigs exhibit greater thrombogenicity than sheep in a pulmonary valve replacement model using mechanical valves?
Population
Pigs (n = 12) and sheep (n = 5)
Comparison
Pigs vs sheep undergoing pulmonary valve replacement with a bileaflet mechanical valve without postoperative antithrombotics
Design
Preclinical animal comparative study
Follow-up
Up to 5 months or until valve thrombosis
Authors
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Pigs may better model human mechanical valve thrombosis than sheep; leaves open whether this shifts preclinical standards without further validation.
Do pigs exhibit greater thrombogenicity than sheep in a pulmonary valve replacement model using mechanical valves?
Pigs demonstrate superior thrombogenicity compared to sheep in a mechanical pulmonary valve replacement model, supporting their use as the standard preclinical model for valve thrombosis research.
Langenaeken et al. (2023) studied this question.
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