Key result
Prosthetic mitral valve implantation was successfully performed in 11 pigs using modified surgical protocols, with gamma imaging at 24 hours showing most thrombi located on the sewing ring.
Population
11 pigs (weight 52.9 +/- 8.1 kg)
Design
Preclinical
Follow-up
24 hours
Authors
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Supports porcine model for prosthetic valve thrombosis research; leaves open translation to clinical practice.
Pigs can serve as an effective preclinical model for studying thromboembolism from prosthetic heart valves when specific surgical protocols are utilized.
Dewanjee et al. (1997) studied Prosthetic heart valve implantation (thromboembolism model) (n=11). Prosthetic mitral valve implantation with modified surgical protocols was evaluated on Thrombus location and platelet deposition. Prosthetic mitral valve implantation was successfully performed in 11 pigs using modified surgical protocols, with gamma imaging at 24 hours showing most thrombi located on the sewing ring.
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