Key result
Glutaraldehyde-treated bioprosthetic mitral valves implanted in juvenile pigs functioned after 6 months, exhibiting calcification and minor thrombotic depositions comparable to sheep models.
Population
8 female Danish Landrace/Yorkshire pigs, 5-month old, 60-kg
Design
Preclinical, nonblinded assessment
Follow-up
6 months
Authors
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Juvenile pigs may serve as an alternative preclinical model for bioprosthetic mitral valves; leaves open translation to human durability and safety.
Observational (n=8)
Nonblinded
No
The juvenile pig model is a reliable and suitable animal model for long-term preclinical evaluation of bioprosthetic mitral valves, demonstrating comparable degenerative processes to sheep and humans.
Hønge et al. (2011) conducted an observational in Bioprosthetic mitral valve degeneration (n=8). Carpentier-Edwards S.A.V. mitral valve prosthesis was evaluated on Valve function and degeneration at 6 months. Glutaraldehyde-treated bioprosthetic mitral valves implanted in juvenile pigs functioned after 6 months, exhibiting calcification and minor thrombotic depositions comparable to sheep models.
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