Why the study?
Does glycerol treatment of bovine pericardial valves improve host endothelial growth and prevent calcification compared to glutaraldehyde/formaldehyde treatment in animal models?
Population
Juvenile sheep implanted with stentless chordally supported bileaflet pericardial mitral valves, and rats…
Comparison
Bovine pericardial tissue treated with 99.5%… vs Bovine pericardial tissue treated with 0.625%…
Design
Preclinical
Follow-up
125-273 days (sheep), 70 days (rats)
Authors
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Glycerol pretreatment reduces calcification and boosts endothelialization in animal valve models; leaves open clinical viability due to rapid degeneration.
Does glycerol treatment of bovine pericardial valves improve host endothelial growth and prevent calcification compared to glutaraldehyde/formaldehyde treatment in animal models?
While glycerol treatment of pericardial valves improves endothelialization and reduces calcification, it causes rapid tissue degeneration, limiting its viability.
Liao et al. (1993) studied this question.
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