Key result
Bovine pericardium modified with glutaraldehyde and 2,3-butanediol demonstrated favorable mechanical properties, reduced calcification, and comparable hemodynamics to a commercial bioprosthesis in a sheep model.
Why the study?
Bovine pericardium can be used for cardiovascular repair surgeries, but challenges involving biocompatibility and durability remain.
Does modification of bovine pericardium with glutaraldehyde and 2,3-butanediol improve biocompatibility and hemodynamics compared to standard bioprostheses in animal models?
Population
Rats and sheep
Comparison
Bovine pericardium modified with glutaraldehyde and 2,3-butanediol vs commercial bioprosthesis control
Design
Pre-clinical animal study
Follow-up
8 weeks in rats and 180 days in sheep
Authors
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Favorable in sheep model; leaves open translation to human bioprostheses.
Does modification of bovine pericardium with glutaraldehyde and 2,3-butanediol improve biocompatibility and hemodynamics compared to standard bioprostheses in animal models?
Modification of bovine pericardium with glutaraldehyde and 2,3-butanediol improves mechanical properties and anti-calcification in vitro and demonstrates favorable hemodynamics and safety as an aortic valve bioprosthesis in a sheep model.
Ren et al. (2020) studied Aortic valve replacement (pre-clinical model) (n=13). Bovine pericardium modified with glutaraldehyde and 2,3-butanediol vs. Commercial bioprosthesis (PERIMOUNT RSR) was evaluated on Hemodynamic performance and structural changes at 180 days. Bovine pericardium modified with glutaraldehyde and 2,3-butanediol demonstrated favorable mechanical properties, reduced calcification, and comparable hemodynamics to a commercial bioprosthesis in a sheep model.
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