Why the study?
The study was conducted to evaluate the effect of chemical treatment with glutamic acid to avoid calcification of biological cardiac valves.
Does glutamic acid treatment reduce calcification of glutaraldehyde-fixed bovine pericardium in animal models?
Does glutamic acid treatment reduce calcification of glutaraldehyde-fixed bovine pericardium in animal models?
Glutamic acid treatment of glutaraldehyde-fixed bovine pericardium reduces calcification in rat and sheep models while maintaining valvar function, suggesting potential for bioprosthesis manufacturing.
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Supports preclinical anticalcification testing in pericardial valves; leaves open durability and clinical translation.
Braile-Sternieri et al. (2020) studied this question.
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