Key result
Bovine pericardium maintained significantly higher collagen content than porcine aortic valve 90 days after subcutaneous implantation in rats (4.89 vs 2.61 micrograms/mg; p<0.001).
Why the study?
Does bovine pericardium have different biological properties compared to porcine aortic valve before and after subcutaneous implantation in rats?
Population
Rat subcutaneous implantation model using 9 pieces of bovine pericardium and 9 pieces of porcine aortic valve
Comparison
Bovine pericardium fixed in 0.625% glutaraldehyde vs Porcine aortic valve fixed in 0.625%…
Design
Preclinical
Follow-up
90 days
Authors
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Bovine pericardium may offer material advantages for bioprostheses; leaves open translation to human valve durability.
Does bovine pericardium have different biological properties compared to porcine aortic valve before and after subcutaneous implantation in rats?
Absolute Event Rate: 4.89% vs 2.61%
p-value: p=<0.001
Bovine pericardium demonstrates superior intrinsic biological properties, specifically higher collagen content, compared to porcine aortic valve in a rat subcutaneous implantation model.
Liao et al. (1992) studied Bioprosthetic valve substitute evaluation. Bovine pericardium vs. Porcine aortic valve was evaluated on Tissue collagen content (hydroxyproline) after 90 days' implantation (p=<0.001). Bovine pericardium maintained significantly higher collagen content than porcine aortic valve 90 days after subcutaneous implantation in rats (4.89 vs 2.61 micrograms/mg; p<0.001).
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