Key result
Porcine pericardium demonstrated significantly lower calcification and better hydrodynamics compared to bovine pericardium, suggesting it may be more suitable for right heart transcatheter valves.
Why the study?
Porcine pericardium has been used as an alternative to bovine pericardium for smaller transcatheter heart valve delivery diameters, but differences between the materials have not been fully studied.
Does porcine pericardium offer different microstructural, biochemical, mechanical, and hydrodynamic properties compared to bovine pericardium for transcatheter heart valve leaflets?
Population
Bovine pericardium and porcine pericardium leaflet materials and rats for subcutaneous implantation
Comparison
Porcine pericardium vs bovine pericardium
Design
Preclinical in vitro and in vivo comparative study
Authors
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Porcine pericardium may suit lower-profile THVs; leaves open whether it matches bovine durability or hemodynamics clinically.
Does porcine pericardium offer different microstructural, biochemical, mechanical, and hydrodynamic properties compared to bovine pericardium for transcatheter heart valve leaflets?
Porcine pericardium exhibits distinct biochemical, mechanical, and hydrodynamic properties compared to bovine pericardium, suggesting it may be more suitable for right heart system THVs due to lower calcification and better hydrodynamics at lower cardiac outputs.
Chang et al. (2021) studied Transcatheter heart valve materials. Porcine pericardium vs. Bovine pericardium was evaluated on Microstructure, biochemical and mechanical properties, and hydrodynamics. Porcine pericardium demonstrated significantly lower calcification and better hydrodynamics compared to bovine pericardium, suggesting it may be more suitable for right heart transcatheter valves.
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