What question did this study set out to answer?

To evaluate whether yak pericardium can serve as an improved biomaterial for transcatheter aortic valve leaflets compared to conventional bovine and porcine tissues.

November 8, 2021Frontiers in Bioengineering and BiotechnologyOpen Access

Yak Pericardium as an Alternative Biomaterial for Transcatheter Heart Valves

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Why the study?

Current commercial transcatheter heart valves do not fully meet clinical needs, necessitating new biological materials.

Does yak pericardium demonstrate superior biomaterial properties compared to bovine and porcine pericardium for use in transcatheter heart valves?

Key Points

To evaluate whether yak pericardium can serve as an improved biomaterial for transcatheter aortic valve leaflets compared to conventional bovine and porcine tissues.
Assessed extracellular matrix architecture, amino acid composition, thickness, and mechanical integrity of yak pericardium before and after mechanical folding.
Performed in vivo subcutaneous embedding experiments to evaluate inflammatory response and calcification against Australian bovine, local bovine, and porcine pericardium controls.
Yak pericardium exhibited a flat structural profile, regular collagen alignment, and significantly lower average thickness than Australian and local bovine pericardium.
High elastic fiber content conferred superior compression resistance during folding alongside reduced expression of transplantation-related antigens.
In vivo implantation demonstrated lower degrees of inflammation and reduced tissue calcification compared to control pericardial tissues.

Structured PICO

Does yak pericardium demonstrate superior biomaterial properties compared to bovine and porcine pericardium for use in transcatheter heart valves?

Population

Preclinical models (in vitro tissue samples and in vivo subcutaneous embedding model)

Intervention

Yak pericardium

Comparator

Australian bovine pericardium, local bovine pericardium, and porcine pericardium

Outcome

Biomaterial properties including extracellular matrix structure, mechanical properties, inflammatory response, and calcificationsurrogate

Yak pericardium shows promise as a novel biomaterial for transcatheter heart valves due to its favorable mechanical properties, low immunogenicity, and anti-calcification effects.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Yak pericardium merits evaluation for transcatheter valves; hypothesis-generating in animals and should not change practice.

Cite This Study

Song et al. (2021) studied this question.

synapsesocial.com/papers/6a8bf48872d01ff479e94677 https://doi.org/10.3389/fbioe.2021.766991

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Yak Pericardium as an Alternative Biomaterial for Transcatheter Heart Valves

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Yak Pericardium as an Alternative Biomaterial for Transcatheter Heart Valves

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider