March 1, 1996Journal of Biomedical Materials ResearchOpen Access

Influence of stress on calcification of delipidated bovine pericardial tissue employed in construction of cardiac valves

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Why the study?

Does delipidating chemical treatment prevent calcification in bovine pericardial tissue subjected to mechanical stress?

Population

Handmade bovine pericardial bioprostheses tissue samples

Comparison

Delipidating chemical treatment followed by… vs Glutaraldehyde treatment alone and tissue…

Design

Preclinical

Follow-up

60 days

Authors

EJE. Jorge‐HerreroHospital Universitario Puerta de Hierro Majadahonda PFP. Fern�ndezUniversidad Complutense de Madrid CECristina EscuderoUniversity of Tübingen

Discussion

Member takes

Implication

Mechanical stress overrides delipidation benefits against calcification in pericardial tissue; leaves open combined interventions for durable bioprosthetic valves.

Structured PICO

Does delipidating chemical treatment prevent calcification in bovine pericardial tissue subjected to mechanical stress?

Population

Handmade bovine pericardial bioprostheses tissue samples

Intervention

Delipidating chemical treatment (chloroform/methanol and glutaraldehyde) followed by mechanical stress (100 x 10^6 cycles) and subcutaneous implantation

Comparator

Glutaraldehyde treatment alone (control) and tissue portions not subjected to mechanical stress

Outcome

Tissue calcification (calcium accumulation) after 21 and 60 days of subcutaneous implantationsurrogate

Mechanical stress negates the anti-calcification benefits of delipidating chemical treatments in bovine pericardial tissue used for bioprosthetic valves.

Cite This Study

Jorge‐Herrero et al. (1996) studied this question.

synapsesocial.com/papers/6a742dfebd21f773de3920f9 https://doi.org/10.1002/(sici)1097-4636(199603)30:3<411::aid-jbm16>3.0.co;2-m

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Implication

Mechanical stress overrides delipidation benefits against calcification in pericardial tissue; leaves open combined interventions for durable bioprosthetic valves.

Influence of stress on calcification of delipidated bovine pericardial tissue employed in construction of cardiac valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Influence of stress on calcification of delipidated bovine pericardial tissue employed in construction of cardiac valves

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider