Why the study?
Do various preimplantation anticalcification treatments reduce calcification of bioprosthetic heart valves in a large animal intracardiac model?
Population
Young sheep undergoing mitral and tricuspid valve replacements with bioprosthetic heart valves
Design
Preclinical
Authors
Loading...
Large-animal intracardiac testing reveals limited anticalcification benefit; leaves open translation of preclinical strategies to human bioprostheses.
Do various preimplantation anticalcification treatments reduce calcification of bioprosthetic heart valves in a large animal intracardiac model?
Anticalcification treatments effective in small animal subcutaneous models may not translate to intracardiac large animal models, highlighting the need for rigorous preclinical validation.
Jones et al. (1989) studied this question.
Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context: