Key result
A practically feasible long-term porcine model for mitral valve replacement was established, with 14 of 16 pigs surviving to 1 month without signs of heart failure.
Population
16 pigs (60-kg)
Design
Preclinical, allocated
Follow-up
1 month
Authors
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Enables preclinical mitral prosthesis testing in a long-term porcine model; leaves open human translation pending further validation.
A long-term porcine model for mitral valve replacement is practically feasible and serves as a platform for preclinical testing of heart valve prostheses.
Smerup et al. (2004) studied Mitral valve replacement (animal model) (n=16). Mitral valve replacement with mechanical prostheses was evaluated on 1-month survival and feasibility. A practically feasible long-term porcine model for mitral valve replacement was established, with 14 of 16 pigs surviving to 1 month without signs of heart failure.
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