Key result
A novel technique for placing a mechanical heart valve in the descending thoracic aorta without cardiac bypass was performed in 6 sheep, with all 4 survivors developing clot formation at the hinges.
Authors
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Thrombosis in all survivors cautions against clinical translation; leaves open need for device or anticoagulation refinements in preclinical models.
Steven W. Marra Matthew M. Puc (2001) studied Prosthetic heart valve thrombogenicity (n=6). Placement of a mechanical heart valve in parallel with the descending thoracic aorta without cardiac bypass was evaluated on Thrombogenicity and valve function. A novel technique for placing a mechanical heart valve in the descending thoracic aorta without cardiac bypass was performed in 6 sheep, with all 4 survivors developing clot formation at the hinges.
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