Key result
Orthotopic implantation of 19-mm bileaflet mechanical aortic valves in adult sheep was technically feasible, with 100% survival to 150 days and no clinically significant thrombus or paravalvular leaks.
Why the study?
Is it technically feasible to orthotopically implant mechanical aortic valves in adult domestic sheep to create a reproducible preclinical model?
Population
3 adult domestic sheep (mean age 22 weeks, mean weight 76 kg)
Design
Preclinical
Follow-up
150 days
Authors
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Establishes reproducible sheep model for mechanical aortic valve testing; leaves open validation for novel designs and clinical translation.
Is it technically feasible to orthotopically implant mechanical aortic valves in adult domestic sheep to create a reproducible preclinical model?
Orthotopic implantation of mechanical aortic valves in adult sheep is technically feasible and reproducible, providing a valuable preclinical model for evaluating new valve designs.
Salerno et al. (1998) studied Aortic valve replacement model (n=3). Orthotopic implantation of 19-mm bileaflet mechanical aortic valves was evaluated on Survival and clinical well-being. Orthotopic implantation of 19-mm bileaflet mechanical aortic valves in adult sheep was technically feasible, with 100% survival to 150 days and no clinically significant thrombus or paravalvular leaks.
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