Key result
Orthotopic implantation of 19-mm stentless bioprosthetic aortic valves in juvenile sheep is a feasible model, with 52% of animals surviving to elective sacrifice at 150 days.
Why the study?
Is it technically feasible and reproducible to evaluate orthotopically implanted 19-mm stentless bioprosthetic aortic valves in a juvenile sheep model?
Population
27 juvenile domestic sheep
Design
Preclinical
Follow-up
150 days
Authors
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Juvenile sheep model enables chronic small-valve testing; leaves open translation to human durability assessment.
Is it technically feasible and reproducible to evaluate orthotopically implanted 19-mm stentless bioprosthetic aortic valves in a juvenile sheep model?
Orthotopic implantation of 19-mm stentless bioprosthetic aortic valves in juvenile sheep is a feasible and reproducible model for chronic valve evaluation.
Ouyang et al. (1998) studied Aortic valve replacement (n=27). Orthotopic implantation of 19-mm stentless bioprosthetic aortic valves was evaluated on Survival to elective sacrifice after postoperative day 150. Orthotopic implantation of 19-mm stentless bioprosthetic aortic valves in juvenile sheep is a feasible model, with 52% of animals surviving to elective sacrifice at 150 days.
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