What does this research mean for the field?

Shenhua tablets exert renoprotective effects in IgA nephropathy by modulating key metabolic pathways, including the TCA cycle and glycolysis, and normalizing abnormal urine metabolite levels. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine the renoprotective efficacy and explore the metabolic mechanisms of Shenhua tablets in an experimental model of IgA nephropathy.

April 7, 2025Biomedical Chromatography

Urine Metabolomics Reveals the Intervention Effects and Mechanism of Shenhua Tablets in IgA Nephropathy

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Authors

PLPing LiPowerChina (China)FYFengting YinHeilongjiang University of Chinese Medicine YZYing ZhengChinese PLA General Hospital

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Implication

Animal study reveals Shenhua tablets alleviate kidney damage and urinary abnormalities in IgA nephropathy rats, indicating protection via metabolic pathway reprogramming.

Key Points

To determine the renoprotective efficacy and explore the metabolic mechanisms of Shenhua tablets in an experimental model of IgA nephropathy.
Induced IgA nephropathy in a rat model using Thy-1 antibodies.
Assessed renal protective actions by measuring 24-hour urinary protein, albumin-to-creatinine ratio, inflammatory cytokines (IL-1β, TNF-α, IL-6), and kidney histopathology.
Utilized urine metabolomics techniques to identify disease biomarkers and map perturbed metabolic pathways modulated by Shenhua tablets.
Shenhua tablets significantly lowered 24-hour urine protein, albumin-to-creatinine ratio, IL-1β, TNF-α, and IL-6 levels, alleviated renal tissue injury, and repressed mesangial cell proliferation.
Identified 17 urine biomarkers characteristic of IgA nephropathy, 14 of which were restored to normal levels following Shenhua tablet administration.
Treatment modulated key pathways including the TCA cycle, glycolysis/gluconeogenesis, pyruvate metabolism, and β-alanine metabolism, increasing citric and succinic acid while decreasing pyruvic acid, L-lactic acid, uracil, and malonic semialdehyde.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6aa93e2cce29879c7a0e099a https://doi.org/10.1002/bmc.70078

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Implication

Animal study reveals Shenhua tablets alleviate kidney damage and urinary abnormalities in IgA nephropathy rats, indicating protection via metabolic pathway reprogramming.

Urine Metabolomics Reveals the Intervention Effects and Mechanism of Shenhua Tablets in IgA Nephropathy

Discussion

Member takes

Implication

Key Points

Cite This Study

Urine Metabolomics Reveals the Intervention Effects and Mechanism of Shenhua Tablets in IgA Nephropathy

Discussion

Member takes

Implication

Key Points

Cite This Study

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