What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: African swine fever virus (ASFV) (n=1207). Intervention: ASFV carrier status. Primary outcome: ASFV detection in internal organ tissues of healthy pigs by PCR.

What does this research mean for the field?

Asymptomatic domestic pigs in endemic smallholder farming systems can harbor African swine fever virus in their internal organ tissues, indicating the existence of healthy carrier pigs that may contribute to disease persistence. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

July 1, 2017Journal of General VirologyOpen Access

Detection of African swine fever virus in the tissues of asymptomatic pigs in smallholder farming systems along the Kenya–Uganda border: implications for transmission in endemic areas and ASF surveillance in East Africa

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Key result

Tissue PCR reveals ~16% of healthy pigs in endemic areas are asymptomatic ASFV carriers.

n=1,207

Population

1107 pigs and 100 pigs in Kenya and Uganda, plus 44 healthy pigs for internal organ tissue testing

Design

Cross-sectional

Authors

EAEdward Okoth AbworoInternational Livestock Research Institute COCynthia OnzereWashington State University JAJoshua O. AmimoAnimal, Food and Health Sciences

Discussion

Member takes

Implication

May indicate asymptomatic ASFV carriers in endemic pigs; hypothesis-generating and requires larger prospective studies before informing control policies.

Study Design

Type

Cross-Sectional (n=1,207)

Multicenter

Yes

Structured PICO

Population

1,207 local pigs in Kenya and Uganda monitored for ASFV prevalence via cross-sectional and longitudinal surveys.

Outcome

African swine fever virus (ASFV) prevalence and detection in serum, blood, and tissues using PCR and ELISAsurrogate

Healthy carrier pigs may play a role in African swine fever virus outbreaks in endemic areas, highlighting the need for tissue-based surveillance.

Limitations

The triggers for outbreaks remain unclear and require further investigation.

Cite This Study

Abworo et al. (2017) conducted a cross-sectional in African swine fever virus (ASFV) (n=1,207). ASFV carrier status was evaluated on ASFV detection in internal organ tissues of healthy pigs by PCR. PCR testing of internal organ tissues from 44 healthy pigs revealed that 15.9% were positive for ASFV, indicating the presence of asymptomatic carrier pigs in endemic areas.

synapsesocial.com/papers/6aa93e5a65360feaf702c07a https://doi.org/10.1099/jgv.0.000848

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Implication

May indicate asymptomatic ASFV carriers in endemic pigs; hypothesis-generating and requires larger prospective studies before informing control policies.

Detection of African swine fever virus in the tissues of asymptomatic pigs in smallholder farming systems along the Kenya–Uganda border: implications for transmission in endemic areas and ASF surveillance in East Africa

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Detection of African swine fever virus in the tissues of asymptomatic pigs in smallholder farming systems along the Kenya–Uganda border: implications for transmission in endemic areas and ASF surveillance in East Africa

Discussion

Member takes

Implication

Study Design

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider