Process Development of Halaven®: Synthesis of the C14-C35 Fragment via Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization

Charles E. Chase; Brian C. Austad; Farid Benayoud; Trevor L. Calkins; Silvio Campagna; Hyeong-Wook Choi; William J. Christ; Robert Costanzo; James Cutter; Atsushi Endo; Francis G. Fang; Yongbo Hu; Bryan M. Lewis; Michael D. Lewis; Shawn McKenna; Thomas A. Noland; John D. Orr; Marc Pesant; Matthew Schnaderbeck; Gordon Wilkie; Taichi Abe; Naoki Asai; Yumi Asai; Akio Kayano; Yuichi Kimoto; Yuki Komatsu; Manabu Kubota; Hirofumi Kuroda; Masanori Mizuno; Taiju Nakamura; Takao Omae; Naoki Ozeki; Taeko Suzuki; Teiji Takigawa; Tomohiro Watanabe; Kazuhiro Yoshizawa

doi:10.1055/s-0032-1317920

Abstract

Multikilogram manufacturing process of the Halaven ® C14–C35 fragment is described. The synthesis features convergent assembly of subunits by iterative asymmetric Ni/Cr-mediated coupling executed in fixed equipment.

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Chase et al. (2013) studied this question.

synapsesocial.com/papers/6aa93ec7f486d0383d2555d4 https://doi.org/10.1055/s-0032-1317920

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Process Development of Halaven®: Synthesis of the C14-C35 Fragment via Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization

Abstract

Discussion

Cite This Study

Process Development of Halaven®: Synthesis of the C14-C35 Fragment via Iterative Nozaki-Hiyama-Kishi Reaction-Williamson Ether Cyclization

Abstract

Discussion

Cite This Study

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