Key result
A 7 g/dL transfusion trigger cuts mortality ~45% versus 9 g/dL, reducing rebleeding and complications.
Why the study?
Does a blood transfusion trigger of 7 g/dL improve survival after 6 weeks in patients compared to a 9 g/dL trigger?
Does a blood transfusion trigger of 7 g/dL improve survival after 6 weeks in patients compared to a 9 g/dL trigger?
A restrictive blood transfusion strategy (trigger 7 g/dL) significantly improves 6-week survival and reduces rebleeding and complications compared to a liberal strategy (9 g/dL).
May support restrictive transfusion in bleeding; leaves open confirmation before practice change.
Some 921 patients were randomized to one of two blood transfusion triggers: 7 g/dL or 9 g/dL.Survival after 6 weeks was higher in the 7 g/dL group: 95 versus 91 per cent (hazard ratio 0.55, 95 per cent c.i. 0.33-0.92,P = 0.02).Risk of rebleeding was also lower (10 versus 16 per cent, P = 0.01), and complications were fewer (40 versus 48 per cent, P = 0.02).
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A 2013 study studied this question. A blood transfusion trigger of 7 g/dL improved 6-week survival compared to 9 g/dL (95% vs 91%, HR 0.55, P=0.02) and reduced rebleeding (10% vs 16%) and complications (40% vs 48%).
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