Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model

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Increased mechanical strain exacerbates the vulnerability of human lungs to Pseudomonas aeruginosa infection. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Karen Hoffmann; Ulrike Behrendt; Peter Pennitz; Holger Kirsten; Jessica Pohl; Elena López-Rodríguez; Chantal Weissfuss; Jens Kollmeier; Mario Tönnies; Konrad Steinestel; Martin Witzenrath; Werner Wenzel; Christian Zobel; Geraldine Nouailles

doi:10.1172/jci192454

November 18, 2025Journal of Clinical InvestigationOpen Access

Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model

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Abstract

Using an advanced human lung-on-a-chip model, this study shows that increased mechanical strain can make the lungs more vulnerable to harmful bacteria such as Pseudomonas aeruginosa.

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Hoffmann et al. (2025) studied this question.

synapsesocial.com/papers/6aa93ef7f8a0f2477726402c https://doi.org/10.1172/jci192454

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Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model

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Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model

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Abstract

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