Diazomethane is a valuable derivatizing agent but very difficult to handle for large-scale chemical transformations. We report here the base-induced decomposition of N -methyl- N -nitrosourea under continuous-flow conditions that enables the production up to 19 mol d –1 of diazomethane, at a total flow rate of 53 mL min –1 .
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Rossi et al. (2011) studied this question.
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