What question did this study set out to answer?

To identify and characterize novel coregulatory proteins that interact with p160 nuclear receptor coactivators to regulate gene transcription.

June 8, 2004Journal of Biological ChemistryOpen Access

Identification of a Novel Family of Ankyrin Repeats Containing Cofactors for p160 Nuclear Receptor Coactivators

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Authors

AZAihua ZhangHeilongjiang University of Chinese Medicine PYPercy Luk YeungCancerCare CLChia‐Wei LiGeneral Electric (Spain)

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Implication

Laboratory study demonstrates ANCO-1 inhibits p160-mediated nuclear receptor transactivation, indicating a novel repressive mechanism driven by histone deacetylase recruitment.

Key Points

To identify and characterize novel coregulatory proteins that interact with p160 nuclear receptor coactivators to regulate gene transcription.
Examined protein-protein binding between ANCO family members and the conserved Per-Arnt-Sim domain of p160 coactivators.
Assessed subcellular localization and interaction with histone deacetylases using immunofluorescence staining.
Evaluated functional effects on steroid and nonsteroid receptor-mediated transcription using transient reporter gene assays.
ANCO-1 localized to discrete, novel nuclear foci and co-associated directly with histone deacetylases.
ANCO-1 expression suppressed ligand-dependent transactivation mediated by both steroid and nonsteroid nuclear receptors.

Cite This Study

Zhang et al. (2004) studied this question.

synapsesocial.com/papers/6aa93fddce29879c7a0e0a97 https://doi.org/10.1074/jbc.m403997200

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Implication

Laboratory study demonstrates ANCO-1 inhibits p160-mediated nuclear receptor transactivation, indicating a novel repressive mechanism driven by histone deacetylase recruitment.

Identification of a Novel Family of Ankyrin Repeats Containing Cofactors for p160 Nuclear Receptor Coactivators

Discussion

Member takes

Implication

Key Points

Cite This Study

Identification of a Novel Family of Ankyrin Repeats Containing Cofactors for p160 Nuclear Receptor Coactivators

Discussion

Member takes

Implication

Key Points

Cite This Study

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