Key result
Palliative chemo-immunotherapy shrinks oral squamous cell carcinoma and RV metastases in a single patient.
Case Report (n=1)
Palliative chemo-immunotherapy can lead to significant regression of rare right ventricular cardiac metastasis from oral squamous cell carcinoma.
May support chemo-immunotherapy for rare cardiac metastases from oral cancer; hypothesis-generating and requires prospective validation.
A 58-year-old male with squamous cell carcinoma of the floor of mouth underwent surgical planning for tumor resection and floor of mouth reconstruction. Unexpectedly, preoperative cervico-thoracic computed tomography (CT) indicated possible right ventricular intramural thrombosis, prompting initiation of unfractionated heparin. Follow-up echocardiography revealed no thrombus reduction, raising concerns of intracardiac metastasis. Positron emission tomography with 2-deoxy-2-[fluorine-18]fluoro- D-glucose with computed tomography ( 18 F-FDG PET/CT) showed a hypermetabolic mass in the right ventricle, raising concern for a distant tumor metastasis. Under anti-coagulation, the patient experienced recurrent tumor-related hemorrhage, necessitating urgent lingual artery embolization. Due to disease progression, surgical options were dismissed in favor of palliative chemo-immunotherapy, which both led to significant regression of both primary and metastatic lesions.
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Marreros et al. (2024) conducted a case report in Squamous cell carcinoma of the oral cavity with cardiac metastasis (n=1). Palliative chemo-immunotherapy was evaluated on Tumor regression. Palliative chemo-immunotherapy led to significant regression of both primary oral squamous cell carcinoma and right ventricular metastatic lesions in a 58-year-old male.
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