Why the study?
The independent associations of psychiatric disorders with atrial fibrillation and acute coronary syndrome, while accounting for psychiatric comorbidity and age-related differences, remain unclear.
Are depression, anxiety disorders, and bipolar disorder independently associated with atrial fibrillation and acute coronary syndrome in hospitalized adults?
Population
23,713,289 discharge records of hospitalized adults aged 18-90 years
Comparison
Depression, anxiety disorders, and bipolar disorder vs their absence
Design
Retrospective cross-sectional analysis
Key result
Depression was associated with higher odds of atrial fibrillation (OR 1.041; 95% CI 1.037-1.045), whereas anxiety, bipolar disorder, and depression were associated with lower odds of ACS.
Authors
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These associations warrant no clinical action; cross-sectional data leaves causality open for longitudinal confirmation.
Cross-Sectional (n=23,068,920)
Yes
Are depression, anxiety disorders, and bipolar disorder independently associated with atrial fibrillation and acute coronary syndrome in hospitalized adults?
Odds Ratio: 1.041 (95% CI 1.037–1.045)
In a large national database, psychiatric disorders demonstrated small but significant, outcome-specific associations with AF and ACS, highlighting the need for longitudinal studies to determine causality.
Suliman et al. (2026) conducted a cross-sectional in Atrial fibrillation and acute coronary syndrome (n=23,068,920). Psychiatric disorders (depression, anxiety disorders, bipolar disorder) vs. No psychiatric disorder was evaluated on Atrial fibrillation (associated with depression) (OR 1.041, 95% CI 1.037-1.045). Depression was associated with higher odds of atrial fibrillation (OR 1.041; 95% CI 1.037-1.045), whereas anxiety, bipolar disorder, and depression were associated with lower odds of ACS.