Targeted optical uncaging of an adenosine A1 receptor agonist regulates excitability of hippocampal slices derived from epileptic mice

Photocaged adenosine A 1 receptor (A 1 R) agonists combined with spatiotemporally selective illumination represents a promising therapeutic strategy for mesial temporal lobe epilepsy (mTLE). This ex vivo study investigated whether the A 1 R agonist N 6 -cyclopentyladenosine (CPA) suppresses hippocampal excitability in the intrahippocampal kainic acid (IHKA) mouse model and whether photocaged CPA (cCPA) enables subregion-selective and closed-loop reduction of hippocampal excitability.