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April 12, 2017Histopathology

Histological features of malignancy correlate with growth patterns and patient outcome in lung adenocarcinoma

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Authors

JMJohanna M. MäkinenKLK. LaitakariSJShirley Johnson

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Overview

Cohort study demonstrates malignancy features correlate with tumor architecture in lung adenocarcinoma, questioning the necessity of a parallel grading system.

Key Points

  • To evaluate classic histological features of malignancy in relation to architectural growth patterns and patient survival in lung adenocarcinoma.
  • Evaluated 112 surgically resected stage I–IV pulmonary adenocarcinomas according to the IASLC/ATS/ERS architectural classification.
  • Assessed classic histological parameters—including nuclear atypia, mitotic activity, tumour necrosis, and invasion patterns—and correlated them with architectural patterns and clinical outcomes.
  • A solid predominant pattern significantly correlated with increased nuclear atypia (P = 0.027), mitotic activity (P < 0.001), tumour necrosis (P < 0.001), and lymphovascular invasion (P = 0.001), while a non-predominant solid pattern linked to intra-alveolar spread (P = 0.004).
  • The presence of a non-predominant lepidic component inversely correlated with nuclear atypia (P = 0.002), mitotic rate (P = 0.009), and necrosis (P < 0.001).
  • Reduced disease-specific survival was significantly associated with tumour size (P < 0.001), mitotic activity (P = 0.019), tumour necrosis (P = 0.002), lymphovascular invasion (P = 0.001), and visceral pleural involvement (P = 0.001).

Cite This Study

Mäkinen et al. (2017) studied this question.

synapsesocial.com/papers/6aa943da59a7b368e58aaa2bhttps://doi.org/10.1111/his.13236
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