Scandium Trifluoromethanesulfonate (Sc(OTf)3) as a Novel Reusable Lewis Acid Catalyst in Aldol and Michael Reactions

All articles of this category In the presence of a catalytic amount of scandium trifluoromethanesulfonate (Sc(OTf) 3 ), aldol and Michael reactions of silyl enolates with aldehydes, acetals, and α,β-unsaturated ketones proceed smoothly to give the corresponding adducts in high yields. The catalyst can be recovered and reused, and is available in both organic and aqueous solvents. Aqueous formaldehyde and chloroacetaldehyde solution react directly with a silyl enolate to afford the corresponding aldol adducts in good yields, respectively.