Nano-zirconium-silicate solid-phase extraction method for the rapid quantification of pyrrolizidine alkaloids from plant extracts by UHPLC-QTOF-MS

and demonstrated a co-efficient of variance below ± 3 % with a % relative error below ± 15. The presented analytical approach was also tested for the determination of PA from contaminated Verbenae herba extract with success. The presented scheme improves the clean-up efficacy of the already used stationary phases for PA analysis and provides a great alternative analytical tool for the isolation of PAs from plant extracts.