Key result
High-risk gastrointestinal stromal tumors are linked to lower preoperative lipid levels versus low-risk tumors.
Why the study?
The study was conducted to investigate the characteristics and clinical significance of serum lipids in patients with gastrointestinal stromal tumors.
Observational (n=694)
Yes
Serum lipid levels correlate with clinical and pathological characteristics of GIST and may help distinguish benign from malignant tumors.
Answers are grounded in this paper and cite their sources.
Preoperative lipids should not guide GIST risk assessment; hypothesis-generating association requires prospective validation.
BACKGROUND: To investigate the characteristics and clinical significance of serum lipids in patients with gastrointestinal stromal tumors (GISTs). METHODS: The clinical and pathological data of 694 GIST patients in Liyuan hospital and Union hospital from 2012 to 2016 were retrospectively analyzed. Blood lipid levels in patients with varying degrees of risk were compared. RESULTS: The findings showed that LDL-C, HDL-C, and CHOL increased significantly in women, and CD34 positive. In patients with tumors size less than 5 cm in diameter, TG, HDL-C, and CHOL were significantly higher. TG levels were significantly higher in DOG-1 (a marker and has a high specificity and sensitivity in the diagnosis of GIST) positive patients than in DOG-1 negative patients (P < 0.05). S-100 positive patients had lower HDL-C levels than S-100 negative patients (P < 0.05). Lipids indexes were found to be correlated with GIST risk stratification and tumor site (P < 0.05). TG/HDL-C was were significantly different among patients with GIST in different locations (P < 0.05). CONCLUSION: The clinical and pathological characteristics of the patients with GIST are closely related to the level of blood lipids. To a certain extent, information about level of blood lipids can be helpful for distinguishing benign and malignant GIST.
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Liu et al. (2022) conducted an observational in Gastrointestinal stromal tumors (GISTs) (n=694). Preoperative serum lipid levels vs. Low-risk vs high-risk GIST stratification was evaluated on Association between blood lipid levels and GIST risk stratification (p=<0.05). High-risk gastrointestinal stromal tumor patients had significantly lower preoperative levels of triglycerides, HDL-C, LDL-C, and total cholesterol compared to low-risk patients (P < 0.05).
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