Key result
A model combining NT-proBNP, RV remodeling index, and 6MWD strongly predicts death or lung transplantation.
Why the study?
Prognosis in PAH is closely related to right ventricular function indexes, and whether clinical network graphs can inform risk stratification remained unknown.
Cohort (n=231)
Effect estimate: C-index 0.81 (95% CI 0.77-0.85)
Clinical network graph analysis identifies NT-proBNP as a central hub in PAH and yields a strong prognostic model (C-index 0.81) for predicting death or lung transplantation.
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May aid risk stratification for transplant referral; leaves open prospective validation and outcome impact.
Haddad et al. (2021) conducted a cohort in Pulmonary arterial hypertension (n=231). Clinical network features (NT-proBNP, right ventricular end-systolic remodeling index, 6MWD) was evaluated on combined end point of death or lung transplantation (C-index 0.81, 95% CI 0.77-0.85). A prognostic model combining NT-proBNP, right ventricular end-systolic remodeling index, 6MWD, and other features strongly predicted death or lung transplantation (C-index 0.81; 95% CI 0.77-0.85).
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