Key result
High-fiber diet reduces plasma and adipose ICAM-1 levels in rats with hypercholesterolemia.
Why the study?
Diet-induced hypercholesterolemia increases oxidative stress and endothelial ICAM-1 expression, while high-fiber diets may reduce lipolysis and indirectly decrease ICAM-1 expression.
Does a high-fiber diet reduce ICAM-1 levels and expression in rats with diet-induced hypercholesterolemia?
Does a high-fiber diet reduce ICAM-1 levels and expression in rats with diet-induced hypercholesterolemia?
A high-fiber diet reduces inflammatory markers (ICAM-1) in a rat model of diet-induced hypercholesterolemia.
Hypothesis-generating for fiber modulating ICAM-1 in hypercholesterolemia models; human trials required before clinical consideration.
BACKGROUND AND OBJECTIVES: Hypercholesterolemia triggered by high-fat and high-fructose diets increases Reactive Oxygen Species production, causing oxidative stress and increasing the expression of Intercellular Adhesion Molecule-1 (ICAM-1) in endothelial cells as a form of inflammatory response. High-fiber diet could restrict lipolysis in adipose tissue, decreasing the secretion of pro-inflammatory cytokines while indirectly decreasing the expression of ICAM-1. METHODS: The research analyzed beneficial effects of high-fiber diet divided into five groups: normal (N); hypercholesterolemia (HC); HC + 1.04 g fiber/rat/day (HFD1); HC + 2.07 g fiber/rat/day (HFD2) and HC + 3.11 g fiber/rat/day (HFD3) for 6-weeks intervention on the level and expression of ICAM-1 in rats induced by high-fat and high-fructose diets. RESULTS: The administration of a high-fiber diet reduced the levels of ICAM-1 plasma hypercholesterolemia rats (HFD1, HFD2 and HFD3) when compared with the hypercholesterolemia group ( p < 0.001) without fiber administration. In addition, the administration of a high-fiber diet also decreased ICAM-1 gene expression in rat adipose tissue when compared with the hypercholesterolemia group ( p < 0.05). The decreased plasma levels of ICAM-1 were not correlated with the reduced ICAM-1 gene expression in rat adipose tissue after administration of a high-fiber diet. CONCLUSIONS: The high-fiber diet administration was able to decrease expression and level of ICAM-1 in hypercholesterolemia rats induced by high-fat and high-fructose diets.
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Danuyanti et al. (2019) studied Hypercholesterolemia. High-fiber diet vs. Hypercholesterolemia group without fiber administration was evaluated on Levels of ICAM-1 plasma (p=< 0.001). A high-fiber diet significantly reduced plasma levels (p<0.001) and adipose tissue gene expression (p<0.05) of ICAM-1 in rats with hypercholesterolemia.
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