Key result
Malnutrition in elderly hypertensives linked to higher 24-hour, daytime, and nighttime systolic BP.
Why the study?
Malnutrition may negatively influence cardiovascular outcomes, but its relationship with ambulatory blood pressure in elderly hypertensive patients was not established.
Is malnutrition (assessed by GNRI) associated with higher ambulatory blood pressure in elderly hypertensive patients?
Observational (n=626)
Is malnutrition (assessed by GNRI) associated with higher ambulatory blood pressure in elderly hypertensive patients?
p-value: p=≤.001
Malnutrition, as assessed by the Geriatric Nutritional Risk Index, is independently associated with higher ambulatory systolic blood pressure in elderly hypertensive patients.
Malnutrition may mark higher ambulatory SBP burden in elderly hypertensives; leaves open whether nutritional interventions improve control.
BACKGROUND: Malnutrition may negatively influence cardiovascular outcomes. We investigated the association between geriatric nutritional risk index (GNRI) and ambulatory blood pressure in elderly patients with hypertension. METHODS: Our study included 235 elderly hypertensive patients with malnutrition (GNRI ≤98) and 391 patients with normal nutrition (GNRI > 98). All patients underwent ambulatory blood pressure monitoring and assessment of nutritional status including total protein, prealbumin, and serum albumin. RESULTS: Patients with malnutrition, compared with normal nutrition, were older, and had a significantly (P ≤ .05) higher serum creatinine, and lower body weight, estimated glomerular filtration rate, serum low density lipoprotein cholesterol, serum total protein, prealbumin, and albumin, body mass index and GNRI (P ≤ .01). After multivariable adjustment, malnourished patients had significantly higher 24-h, daytime and nighttime systolic blood pressure (P ≤ .001). Lower GNRI was independently associated with higher 24-h, daytime and nighttime systolic blood pressure after adjustment for confounding factors (P < .05). CONCLUSIONS: Elderly hypertensive patients with malnutrition had higher systolic blood pressure than those with normal nutrition. GNRI was associated with 24-h, daytime and nighttime systolic blood pressure.
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Wang et al. (2025) conducted an observational in Hypertension (n=626). Malnutrition (GNRI ≤98) vs. Normal nutrition (GNRI > 98) was evaluated on 24-h, daytime and nighttime systolic blood pressure (p=≤.001). Malnutrition (GNRI ≤98) in elderly hypertensive patients was independently associated with higher 24-h, daytime, and nighttime systolic blood pressure compared to normal nutrition (P≤.001).
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