April 1, 2003The Journal of Urology
Charlson Co-Morbidity Index as a Predictor of Outcome After Surgery for Renal Cell Carcinoma With Renal Vein, Vena Cava or Right Atrium Extension.
Key result
Charlson comorbidity index fails to predict cause-specific survival in surgically treated RCC with tumor thrombus.
- P=0.65
- n=303
Why the study?
Predictors of outcome after surgery for renal cell carcinoma with tumor thrombus are variable, and the effect of co-morbidity on survival had not been studied in these patients.
Does the Charlson co-morbidity index predict cause-specific survival in patients undergoing surgery for renal cell carcinoma with tumor thrombus?
Population
303 patients undergoing surgical resection for renal cell carcinoma with tumor thrombus
Comparison
Charlson co-morbidity index and other clinical/pathologic factors
Design
Retrospective cohort study
Follow-up
10 years
Authors
Discussion
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Implication
In patients undergoing surgery for renal cell carcinoma with tumor thrombus, primary tumor characteristics rather than the Charlson co-morbidity index are the most important predictors of cause-specific survival.
Study Design
Type
Cohort (n=303)
Structured PICO
Does the Charlson co-morbidity index predict cause-specific survival in patients undergoing surgery for renal cell carcinoma with tumor thrombus?
P
Population
303 patients who underwent surgical resection for renal cell carcinoma with tumor thrombus between 1970 and 1998, with survival assessed at 5 and 10 years.
E
Exposure
Surgical resection and assessment of Charlson co-morbidity index
O
Outcome
Cause specific survivalhard clinical
Main Result
p-value: p=0.65
In patients undergoing surgery for renal cell carcinoma with tumor thrombus, primary tumor characteristics rather than the Charlson co-morbidity index are the most important predictors of cause-specific survival.
Limitations
- Retrospective design
Cite This Study
Gettman et al. (2003) conducted a cohort in renal cell carcinoma with tumor thrombus (n=303). Charlson co-morbidity index was evaluated on cause specific survival (p=0.65). The Charlson co-morbidity index did not predict cause-specific survival in patients surgically treated for renal cell carcinoma with tumor thrombus (p=0.65).