Key result
Early circulating lactate linked to ~42% greater odds of poor outcomes.
Why the study?
Elevated blood lactate at admission is associated with poor outcome in critically ill patients, but this association has not been investigated after aneurysmal subarachnoid hemorrhage.
Are early circulating lactate and glucose levels associated with delayed cerebral ischemia and poor outcome in patients with aneurysmal subarachnoid hemorrhage?
Population
285 patients with aneurysmal subarachnoid hemorrhage admitted to ICU within 24 hours in the Netherlands
Comparison
Early circulating lactate and glucose levels
Design
Retrospective cohort study
Follow-up
3 months
Authors
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May refine early prognostication after aneurysmal subarachnoid hemorrhage; leaves open prospective validation before clinical adoption.
Cohort (n=285)
Yes
Are early circulating lactate and glucose levels associated with delayed cerebral ischemia and poor outcome in patients with aneurysmal subarachnoid hemorrhage?
Odds Ratio: 1.42 (95% CI 1.11–1.81)
Early lactate and glucose levels after aneurysmal subarachnoid hemorrhage are independently associated with poor outcome and delayed cerebral ischemia, respectively, and may be useful for prognostic models.
Dijkland et al. (2016) conducted a cohort in aneurysmal subarachnoid hemorrhage (n=285). Early circulating lactate and glucose levels was evaluated on poor outcome (a modified Rankin Scale score of 4, 5, or death at 3 mo) (OR 1.42, 95% CI 1.11-1.81). Early circulating lactate was independently associated with poor outcome (OR 1.42; 95% CI 1.11-1.81), while early glucose was independently associated with delayed cerebral ischemia (OR 1.14).
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