Key result
Symptomatic Brugada syndrome linked to reduced heart rate complexity after exertion versus asymptomatic patients.
Why the study?
Symptoms such as ventricular arrhythmias in Brugada syndrome typically occur at rest, suggesting autonomic nervous system function may be relevant in arrhythmogenesis and needs assessment during physical stress.
Does heart rate complexity analysis during physical stress testing discriminate between symptomatic and asymptomatic patients with Brugada syndrome?
Observational (n=69)
Does heart rate complexity analysis during physical stress testing discriminate between symptomatic and asymptomatic patients with Brugada syndrome?
p-value: p=0.015
Heart rate complexity analysis during physical stress testing reveals lower autonomic nervous system complexity in symptomatic Brugada syndrome patients, potentially aiding in risk stratification.
Post-exertion heart rate complexity may discriminate symptomatic from asymptomatic Brugada syndrome; hypothesis-generating and requires prospective validation.
Symptoms such as ventricular arrhythmias in Brugada syndrome (BS) typically occur at rest, especially during sleep, suggesting that the autonomic nervous system (ANS) function may be relevant in the arrhythmogenesis of the disease. The aim of this work was to assess the ANS response captured by nonlinear heart rate variability (HRV) measures in 69 patients diagnosed with BS, who underwent a standardized physical stress test. Heart rate complexity (HRC) was evaluated by the power-law scaling analysis (β slope) during rest, exercise, recovery and rest post-recovery, in order to discriminate between symptomatic and asymptomatic BS patients. Symptomatic patients showed a significant reduction in HRC in comparison to asymptomatic subjects, after exertion (p = 0.015); during the whole recovery period (p = 0.023), and in particular within the passive recovery phase (p = 0.025), as well as during rest post-recovery (p = 0.022). Based on these results, symptoms could be associated with a lower ANS complexity during the stress test stages where parasympathetic activity is predominant. Therefore, the proposed HRV indicators could be of help in the risk stratification of asymptomatic patients.
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Calvo et al. (2017) conducted an observational in Brugada syndrome (n=69). Symptomatic status vs. Asymptomatic status was evaluated on Heart rate complexity (HRC) evaluated by power-law scaling analysis (β slope) during rest, exercise, recovery and rest post-recovery (p=0.015). Symptomatic Brugada syndrome patients exhibited a significant reduction in heart rate complexity compared to asymptomatic patients after exertion (p=0.015) and during recovery (p=0.023).
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