Key result
Iloprost adds no benefit to N-acetylcysteine against intestinal ischemia-reperfusion injury in rats.
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No added protection with iloprost in this rat model; leaves open need for alternative strategies in intestinal ischemia-reperfusion.
Ischemia-reperfusion injury and thiol/disulfide hemostasis Effects of iloprost and n-acetylcysteine on ischemia-reperfusion injury and thiol/disulfide hemostasis in rats
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Yıldız et al. (2023) studied Intestinal ischemia-reperfusion injury (n=30). Iloprost and N-acetylcysteine vs. Untreated ischemia-reperfusion (IIR) and sham was evaluated on Intestinal damage assessed by Chiu score (p=>0.05). The addition of iloprost to N-acetylcysteine was not more protective than N-acetylcysteine alone against intestinal ischemia-reperfusion injury in rats.
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