Therapeutic effect of recombinant thrombomodulin on the hemostatic and inflammatory response in patients with septic DIC

Noritaka Yada; Kenji Nishio; Tadahiko Seki; Hidetada Fukushima; Yasuyuki Urizono; Michiaki Hata; Kazuo Okuchi

doi:10.3893/jjaam.22.749

January 1, 2011Nihon Kyukyu Igakukai Zasshi Journal of Japanese Association for Acute MedicineOpen Access

Therapeutic effect of recombinant thrombomodulin on the hemostatic and inflammatory response in patients with septic DIC

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Key Points

To evaluate the clinical efficacy of recombinant human soluble thrombomodulin alpha (rTM) on disease severity, coagulation dynamics, and inflammatory response in patients with septic disseminated intravascular coagulation (DIC).
Analyzed hospitalized septic DIC patients (September 2007 to January 2010) with baseline antithrombin (AT) levels ≤70% who received AT substitution, comparing an rTM-treated group (n=12) with a non-rTM control group (n=16).
Monitored serial changes in acute DIC scores, coagulation-fibrinolysis markers (soluble fibrin, thrombin-antithrombin complex, AT activity), and inflammatory mediators (TNF-α, IL-6, HMGB1).
Acute-phase DIC scores improved significantly to a mean below 4 points by day 5 in the TM group compared to day 7 in the control group.
Levels of soluble fibrin (SF) and thrombin-antithrombin complex (TAT) decreased significantly by day 3 only in the TM group; SF remained significantly lower at days 3 and 7 versus controls, while day 3 AT activity was significantly higher in the TM group.
Serum TNF-α, IL-6, and HMGB1 decreased significantly by day 3 in the TM group compared to baseline, with HMGB1 levels significantly lower in the TM group than in the control group at day 3.

Implication

Shows faster DIC score resolution and reduced inflammation with recombinant thrombomodulin in septic DIC, indicating combined anticoagulant and anti-inflammatory benefits.

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Cite This Study

Yada et al. (2011) studied this question.

synapsesocial.com/papers/6aa94e71c924504423cdcf0e https://doi.org/10.3893/jjaam.22.749

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Therapeutic effect of recombinant thrombomodulin on the hemostatic and inflammatory response in patients with septic DIC

Key Points

Implication

Abstract

Discussion

Cite This Study

Therapeutic effect of recombinant thrombomodulin on the hemostatic and inflammatory response in patients with septic DIC

Key Points

Implication

Abstract

Discussion

Cite This Study

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