Key result
Dexmedetomidine yields similar 12-hour opioid requirements compared to propofol for post-CABG sedation.
Why the study?
The effect of substituting dexmedetomidine for propofol during a nationwide propofol shortage on postoperative outcomes after CABG surgery was unclear.
Does dexmedetomidine reduce opioid requirements and time to extubation compared to propofol in adults undergoing elective CABG surgery?
Comparison
Dexmedetomidine vs propofol for postoperative sedation
Design
Single-center retrospective case-control study
Follow-up
24 hours
Authors
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Similar opioid requirements after CABG sedation switch; leaves open effects on extubation or other outcomes in prospective studies.
Case-Control (n=70)
No
Does dexmedetomidine reduce opioid requirements and time to extubation compared to propofol in adults undergoing elective CABG surgery?
Absolute Event Rate: 7% vs 8%
p-value: p=0.1
Dexmedetomidine substitution for propofol for postoperative sedation after CABG surgery resulted in similar opioid requirements and time to extubation.
Reichert et al. (2011) conducted a case-control in Coronary artery bypass graft (CABG) surgery (n=70). Dexmedetomidine vs. Propofol was evaluated on Opioid requirements in the first 12 hours after arrival to the ICU (morphine equivalents) (p=0.1). Dexmedetomidine substitution for postoperative sedation after CABG surgery resulted in similar median opioid requirements in the first 12 hours compared to propofol (7.0 mg vs 8.0 mg; p=0.1).
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