Key result
CMR shows echocardiography overestimates LV mass and underestimates LV volumes, detecting global LGE in ~77%.
Why the study?
The non-invasive assessment of amyloid heart disease is challenging and published studies have been inconsistent regarding LGE patterns associated with amyloid cardiomyopathy.
Does cardiac magnetic resonance differ from echocardiography in assessing LV morphology and function in patients with AL amyloid cardiomyopathy?
Observational (n=22)
Does cardiac magnetic resonance differ from echocardiography in assessing LV morphology and function in patients with AL amyloid cardiomyopathy?
p-value: p=<0.01
Echocardiography significantly overestimates LV mass and underestimates LV volumes compared to CMR in AL amyloid cardiomyopathy, and global LGE patterns on CMR are highly prevalent.
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Echocardiography-derived LV metrics warrant caution in AL amyloid cardiomyopathy; leaves open whether CMR improves risk stratification or outcomes.
Fikrle et al. (2014) conducted an observational in AL amyloid cardiomyopathy (n=22). Cardiac magnetic resonance (CMR) vs. Echocardiography was evaluated on LV end-diastolic volume and LV mass (p=<0.01). Echocardiography significantly overestimates LV mass (P<0.001) and underestimates LV volumes (P<0.01) compared to CMR, which detected global LGE patterns in 77% of patients.
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