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PURPOSE: To report agranulocytosis associated with lamotrigine (LTG) in a patient with a brain tumor. METHODS: A 59-year-old woman with a low-grade glioma and difficult-to-control partial seizures developed agranulocytosis between 9 and 14 weeks after starting LTG. The patient underwent chemotherapy 2 years previously. RESULTS: After stopping LTG, the agranulocytosis persisted for 9 days despite 7 days of granulocyte-colony-stimulating factor (G-CSF), and ultimately resolved. CONCLUSIONS: In this case, the use of LTG was associated with the development of agranulocytosis, and it is likely that this association was causative.
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Fadul et al. (2002) studied this question.
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