Key result
Intra-operative Pseudomonas aeruginosa during pediatric appendectomies is linked to a ~2-day longer hospital stay.
Why the study?
Appendicitis is a common pediatric surgical emergency requiring empirical antibacterial therapy, so identifying intra-operative bacterial pathogens was investigated to guide surgical antimicrobial prophylaxis.
Population
304 patients younger than 18 years undergoing appendectomy across a multisite London hospital
Design
Retrospective analysis
Authors
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May support extended empirical coverage in pediatric appendicitis with peritonitis; leaves open whether this shortens stay in prospective trials.
Observational (n=304)
Yes
Absolute Event Rate: 7% vs 5%
p-value: p=0.011
A high prevalence of Pseudomonas spp. and co-amoxiclav-resistant E. coli in pediatric appendicitis with peritonitis suggests a need for extended empirical antibacterial coverage.
Bhaskar et al. (2023) conducted an observational in Paediatric appendicitis (n=304). Intra-operative isolation of Pseudomonas aeruginosa vs. Non-Pseudomonas cultured intra-operative cases was evaluated on Length of hospital stay (days) (p=0.011). Isolation of Pseudomonas aeruginosa from intra-operative sampling during paediatric appendectomies was associated with a significantly greater length of hospital stay (7.0 vs. 5.0 days) compared to non-Pseudomonas cases.
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