Key result
Hypoxia alters extracellular vesicle release, molecular content, and function in cancer and chronically inflamed tissues.
This review highlights the role of hypoxia in modulating extracellular vesicles in cancer and inflammation, pointing to potential diagnostic applications.
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May inform hypoxia-related EV diagnostics in cancer and inflammation; leaves open prospective clinical validation.
Hypoxia is a severe stress condition often observed in cancer and chronically inflamed cells and tissues. Extracellular vesicles play pivotal roles in these pathological processes and carry biomolecules that can be detected in many biofluids and may be exploited for diagnostic purposes. Several studies report the effects of hypoxia on extracellular vesicles' release, molecular content, and biological functions in disease. This review summarizes the most recent findings in this field, highlighting the areas that warrant further investigation.
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Venturella et al. (2021) conducted a review in Cancer and Inflammation. Hypoxia was evaluated. Hypoxia influences the release, molecular content, and biological functions of extracellular vesicles in cancer and chronically inflamed cells and tissues.
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