Key result
Manidipine reduces UAE more than amlodipine in diabetic hypertension, independent of blood pressure reduction.
Why the study?
Does manidipine reduce urinary albumin excretion compared to amlodipine in diabetic patients with uncontrolled hypertension, microalbuminuria, and preserved renal function?
RCT
Does manidipine reduce urinary albumin excretion compared to amlodipine in diabetic patients with uncontrolled hypertension, microalbuminuria, and preserved renal function?
Manidipine reduces urinary albumin excretion more effectively than amlodipine in diabetic hypertensive patients, independent of blood pressure reduction.
Manidipine was associated with greater albuminuria reduction than amlodipine; leaves open renal outcome benefits in diabetic hypertension pending RCTs.
AIMS: In AMANDHA trial, the addition of manidipine, but not amlodipine, in diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function resulted in a large decrease of urinary albumin excretion (UAE) despite similar blood pressure (BP) reductions. Factors associated with the reduction of UAE were analyzed. METHODS: For this purpose, a multivariable analysis was performed. RESULTS: Although after 6 months of treatment, manidipine and amlodipine decreased BP to a similar extent, reductions of UAE were higher with manidipine. The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were associated with changes in UAE. CONCLUSION: The assigned treatment, changes in mean BP, sympathetic tone and glycemic control were independently associated with changes in UAE. Compared with amlodipine, manidipine reduced UAE to a higher extent, independently of BP reduction.
No takes yet. Share an insight, caveat, or question.
Saiz-Satjes et al. (2016) conducted an RCT in Diabetic patients with uncontrolled hypertension, microalbuminuria and preserved renal function. Manidipine vs. Amlodipine was evaluated on Reduction of urinary albumin excretion (UAE). Manidipine reduced urinary albumin excretion to a higher extent than amlodipine in diabetic hypertensive patients, independently of blood pressure reduction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: