Key result
Rare G5P[6] rotavirus linked to mild encephalopathy and a reversible splenial lesion.
Why the study?
Few reports have investigated rotavirus genotypes in encephalopathy, and the relationship between genotypes and clinical symptoms remains unclear.
Case Report (n=1)
No
This is the first report of the rare G5P[6] rotavirus genotype isolated from a patient with encephalopathy in Japan.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to rare G5P[6] rotavirus in pediatric encephalopathy; extends genotype spectrum but remains hypothesis-generating.
We report a case of mild encephalopathy with a reversible splenial lesion (MERS) associated with acute gastroenteritis caused by rotavirus (RV) infection. The patient (male, 4 years and 3 months old) was admitted to our hospital for diarrhea and afebrile seizures. Head MRI revealed a hyperintense signal in the splenium of the corpus callosum on DWI and a hypointense signal on the ADC-map. After awakening from sedation, the patient's disturbance of consciousness improved. On day 5 after admission of the illness, the patient was discharged from the hospital in a good condition. Electroencephalography on day 2 after admission was normal. On day 8 of admission, head MRI revealed that the splenial lesion had disappeared. RV antigen-positive stools suggested that RV had caused MERS. This RV genotype was considered to be G5P[6]; it may have spread to humans as a strain reassortment through substitution of porcine RV into human RV gene segments. This extremely rare genotype was detected first in Japan and is not covered by existing vaccines; this is the first sample isolated from encephalopathy patients. Few reports have investigated RV genotypes in encephalopathy; we believe that this case is valuable for studying the relationship between genotypes and clinical symptoms.
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Matsuoka et al. (2013) conducted a case report in Mild encephalopathy with a reversible splenial lesion (MERS) associated with rotavirus infection (n=1). G5P[6] rotavirus infection was evaluated on Clinical and radiological resolution. A rare G5P[6] rotavirus infection was identified in a 4-year-old male with mild encephalopathy and a reversible splenial lesion, which resolved clinically and radiologically within 8 days.
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