Key result
Rotavirus RNA detected in CSF supports the hypothesis of viral spread to the CNS.
Why the study?
Central nervous system localization of rotavirus infection in children with rotavirus gastroenteritis is rare and not well characterized.
Case Report (n=1)
This case report provides molecular evidence supporting the hypothesis that rotavirus can spread from the intestinal tract to the central nervous system, potentially contributing to neurological symptoms.
Answers are grounded in this paper and cite their sources.
Supports considering rotavirus in CSF testing for children with gastroenteritis and meningism; leaves open frequency and mechanisms of CNS spread.
Although case reports have described detection of rotavirus (RV) in extraintestinal sites such as the liver, kidney, and central nervous system (CNS) of children with RV gastroenteritis, CNS localization in RV infection seems to be rare. RT-PCR and nucleotide sequencing detected a G1P[8] strain in the stool and cerebrospinal fluid (CSF) samples of a patient with concurrent RV-associated enteritis and CNS signs. Upon sequence analysis, the viruses detected in the CSF was identical to the virus detected in the stools. In the VP7- and VP4-based phylogenetic dendograms the strain clustered within the G1-Ic sub-lineage and the P[8]-III lineage. This study supports the hypothesis that RV infection was able to spread from the intestinal tract to the CNS, and likely played a role in the onset of neurological disease.
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Medici et al. (2011) conducted a case report in Rotavirus gastroenteritis and meningism (n=1). Rotavirus infection was evaluated on Detection of rotavirus RNA in cerebrospinal fluid and stool. Rotavirus RNA (G1P[8] strain) was detected in both the stool and cerebrospinal fluid of a child with gastroenteritis and meningism, supporting the hypothesis of viral spread to the CNS.
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