Key result
Rotavirus diarrhea was associated with seizures in <4% of patients compared to 7% with bacterial diarrhea, while rotavirus RNA was detected in the CSF of 2 patients with encephalopathy.
Why the study?
Is rotavirus a cause of central nervous system symptoms such as encephalopathy and seizures in children with gastroenteritis?
Population
2 patients with rotavirus gastroenteritis who developed encephalopathy, and patients from 2 large hospital…
Design
Case_report
Authors
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May suggest rotavirus CNS involvement in select cases; hypothesis-generating and should not change practice pending confirmation.
Case Report (n=2)
Yes
Is rotavirus a cause of central nervous system symptoms such as encephalopathy and seizures in children with gastroenteritis?
Absolute Event Rate: 4% vs 7%
The detection of rotavirus RNA in the CSF of patients with encephalopathy suggests a possible association between rotavirus and central nervous system symptoms, though further study is needed to rule out contamination or carriage.
Lynch et al. (2001) conducted a case report in Rotavirus gastroenteritis (n=2). Rotavirus RNA detection in CSF vs. Bacterial diarrhea was evaluated on Seizures as part of discharge diagnosis. Rotavirus diarrhea was associated with seizures in <4% of patients compared to 7% with bacterial diarrhea, while rotavirus RNA was detected in the CSF of 2 patients with encephalopathy.
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