Key result
Fluoxetine and mindfulness therapy show no benefit over usual care for mild depression in T2DM.
Why the study?
Evidence comparing pharmacological and psychological interventions for mild depression in type 2 diabetes mellitus within primary care settings remains limited.
Does fluoxetine, mindfulness therapy, or their combination improve depressive symptoms in individuals with Type 2 Diabetes Mellitus and mild depression compared to treatment as usual?
Population
200 individuals with T2DM and mild depression from Bengaluru
Comparison
Fluoxetine vs mindfulness therapy vs combination treatment vs treatment as usual
Design
Single-blind parallel-group randomized controlled trial
Follow-up
4 months
Authors
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In patients with T2DM and mild depression, neither fluoxetine, mindfulness therapy, nor their combination demonstrated superiority over treatment as usual in reducing depressive symptoms over 4 months.
RCT (n=200)
single-blind
parallel-group
Yes
Does fluoxetine, mindfulness therapy, or their combination improve depressive symptoms in individuals with Type 2 Diabetes Mellitus and mild depression compared to treatment as usual?
Effect estimate: Effect size 0.48 for Mindfulness, 0.45 for Fluoxetine, 0.31 for combination
In patients with T2DM and mild depression, neither fluoxetine, mindfulness therapy, nor their combination demonstrated superiority over treatment as usual in reducing depressive symptoms over 4 months.
Raveendranathan et al. (2026) conducted an RCT in Type 2 Diabetes Mellitus and mild depression (n=200). Fluoxetine, Mindfulness therapy, or combination Fluoxetine + Mindfulness vs. Treatment as usual (TAU) was evaluated on Reduction in depressive symptoms (Effect size 0.48 for Mindfulness, 0.45 for Fluoxetine, 0.31 for combination). Fluoxetine, mindfulness therapy, and their combination did not demonstrate superiority over treatment as usual in reducing depressive symptoms among patients with T2DM and mild depression.
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