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Characteristics of particulate heating mediators in radiofrequency (RF) capacitive hyperthermia were investigated. Four ferromagnetic ferrite particles (Cu (II) Fe (III)2O3, Mg (II) Fe (III)2O3, Mn (II) Fe (III)2O3, and Ni (II) Fe (III)2O3) in addition to magnetite particles and other non-ferromagnetic metal oxide particles (α-Fe2O3, α-Alumina, Ag (II) O, and ZnO) were tested using 8 MHz RF heating device. As a result, ferromagnetic particles could generate heat specifically in RF capacitive, but non-ferromagnetic particles could not. In addition, dispersiblity of particles was an important parameter for heat generation. Temperature increase of Mg (II) Fe (III)2O3 was well improved by sonication. It was shown that alternative magnetic field is generated around ferromagnetic particles in 8 MHz RF electric field and that heat is generated in ferromagnetic particles due to hysteresis loss by the action of alternative magnetic field ; i. e. the same heat generation mechanism with inductive heating.
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Shinkai et al. (2002) studied this question.
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