Key result
Mitochondrial creatine kinase controls ADP delivery to the translocase, revealing heart microcompartmentation.
Why the study?
The control of heart mitochondrial oxygen consumption by ADP availability and the role of creatine kinase in microcompartmentation and energy transport require further elucidation.
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Refines models of cardiac mitochondrial ADP shuttling; leaves open relevance to human heart failure energetics.
Jacobus et al. (1983) studied Heart oxidative phosphorylation. Mitochondrial creatine kinase was evaluated on ADP delivery to the translocase. The forward rate of mitochondrial creatine kinase preferentially controls ADP delivery to the translocase, demonstrating cellular microcompartmentation in heart mitochondrial membranes.
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